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Pheniramine overdose

Brompheniramine maleate; Chlorpheniramine maleate; Dexchlorpheniramine maleate

Pheniramine is a type of medicine called an antihistamine. It helps relieve allergy symptoms. Pheniramine overdose occurs when someone takes more than the normal or recommended amount of this medicine, either by accident or on purpose.

This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with overdoses, call the local emergency number (such as 911), or the local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

Poisonous Ingredient

Pheniramine

Where Found

Pheniramine can be found in these medicines:

  • Advil Allergy & Congestion Relief
  • Advil Allergy Sinus
  • Advil Multi-Symptom Cold & Flu
  • Children's Advil Allergy Sinus
  • Bromfed DM
  • Polmon; Tussicaps
  • Tuxarin ER
  • Tuzistra XR
  • Vituz
  • Zutripro
  • Naphcon-A
  • Visine
  • Visine-A

Other products may also contain pheniramine.

Symptoms

Below are symptoms of an overdose of pheniramine in different parts of the body.

BLADDER AND KIDNEYS

  • Inability to urinate
  • Difficulty urinating

EYES, EARS, NOSE, AND THROAT

  • Blurred vision
  • Dilated (enlarged) pupils
  • Dry mouth
  • Ringing in the ears

HEART AND BLOOD VESSELS

  • Rapid heartbeat
  • Increased blood pressure

NERVOUS SYSTEM

  • Agitation
  • Coma
  • Convulsions (seizures)
  • Delirium, hallucinations
  • Disorientation
  • Drowsiness
  • Fever
  • Nervousness, tremors
  • Unsteadiness, weakness

SKIN

  • Flushed skin
  • Warm skin

STOMACH AND INTESTINES

  • Nausea and vomiting

Home Care

Seek medical help right away. Do not make the person throw up unless poison control or a health care provider tells you to.

Before Calling Emergency

Have this information ready:

  • Person's age, weight, and condition
  • Name of product (as well as the ingredients and strength, if known)
  • Time it was swallowed
  • Amount swallowed
  • If the medicine was prescribed for the person

Poison Control

The local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

You can also get online poison help now at Poisonhelp.org. Just enter the product, poison, or medicine to get expert help.

What to Expect at the Emergency Room

Take the container with you to the hospital, if possible.

Your provider will measure and monitor your vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated. You may receive:

  • Activated charcoal
  • Blood and urine tests
  • Breathing support, including oxygen, or a tube that goes through the mouth into the lungs, and attachment to a breathing machine (ventilator)
  • Chest x-ray
  • CT scan of the brain
  • Electrocardiogram (ECG)
  • Intravenous fluids (given through a vein)
  • Laxative
  • Medicine to treat symptoms
  • Tube through the mouth into the stomach to empty the stomach (gastric lavage)
  • Catheter (thin, flexible tube) into the bladder if person cannot urinate on their own

Outlook (Prognosis)

If the person survives the first 24 hours, chances of recovery are good. Few people die from an antihistamine overdose.

With extremely high doses of antihistamines, serious heart rhythm disturbances may occur, which may result in death.

Open References

References

Aminoff MJ, So YT. Effects of toxins and physical agents on the nervous system. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 86.

Aronson JK. Antihistamines. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:606-618.

Hoppe JA, Monte AA. Anticholinergics. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 140.

 

Review Date: 4/8/2025

Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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