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Hypothalamus

The hypothalamus is an area of the brain that produces hormones that regulate:

  • Body temperature
  • Heart rate
  • Hunger
  • Mood
  • Release of hormones from many glands, especially the pituitary gland
  • Sex drive
  • Sleep
  • Thirst

Information

HYPOTHALAMIC DISEASE

Hypothalamic dysfunction can occur as a result of diseases, including:

  • Genetic causes (often present at birth or during childhood)
  • Infection or inflammation
  • Injury as a result of trauma, surgery or radiation

SYMPTOMS OF HYPOTHALAMIC DISEASE

Because the hypothalamus regulates so many different functions, hypothalamic disease can have many different symptoms, depending on the cause. The most common symptoms are:

  • Increased appetite and rapid weight gain
  • Extreme thirst and frequent urination (diabetes insipidus)
  • Low body temperature
  • Slow heart rate
Open References

References

Christian HC. Anatomy and physiology of the hypothalamus and pituitary. In: Robertson RP, ed. DeGroot's Endocrinology. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 13.

Hafida S, Apovian CM. Obesity and neuroendocrine control of energy stores. In: Melmed S, Auchus RJ, Goldfine AB, Rosen CJ, Kopp PA, eds. Williams Textbook of Endocrinology. 15th ed. Philadelphia, PA: Elsevier; 2025:chap 40.

Weiss RE. Neuroendocrinology and the neuroendocrine system. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 204.

  • Hypothalamus

    Hypothalamus - illustration

    The hypothalamus is a highly complex structure in the brain that regulates many important brain chemicals. Malfunction of this area of the brain may affect basic functions like sleep, appetite, and temperature.

    Hypothalamus

    illustration

  • Brain-thyroid link

    Brain-thyroid link - illustration

    Although the thyroid gland releases the hormones which govern growth and metabolism, the brain (the pituitary and the hypothalamus) manages the release and the balance of the amount of hormones circulated.

    Brain-thyroid link

    illustration

  • Hypothalamus

    Hypothalamus - illustration

    The hypothalamus is a highly complex structure in the brain that regulates many important brain chemicals. Malfunction of this area of the brain may affect basic functions like sleep, appetite, and temperature.

    Hypothalamus

    illustration

  • Brain-thyroid link

    Brain-thyroid link - illustration

    Although the thyroid gland releases the hormones which govern growth and metabolism, the brain (the pituitary and the hypothalamus) manages the release and the balance of the amount of hormones circulated.

    Brain-thyroid link

    illustration

 

Review Date: 4/24/2025

Reviewed By: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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