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Splenic infarction

Splenic infarction is the death of tissue (necrosis) in the spleen due to a blockage in blood flow.

Causes

Common causes of splenic infarction include:

  • Blood clots from the heart
  • Blood cancer, such as lymphoma or leukemia
  • Diseases in which the blood clots more easily, such as sickle cell disease
  • Inflammation of the pancreas or a mass in the pancreas pressing on the blood vessels to the spleen
Open References

References

Mohammed S, Rizvi H .Lymph nodes and extranodal lymphoid tissue, spleen and thymus. In: Cross SS, ed. Underwood's Pathology. 8th ed. Philadelphia, PA: Elsevier; 2025:chap 22.

Ollila TA, Zayac AS, Schiffman FJ. The spleen and its disorders. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 156.

  • Spleen anatomy

    Spleen anatomy - illustration

    The spleen is an organ that filters the blood, stores blood cells, removes old red blood cells, and produces certain white blood cells.

    Spleen anatomy

    illustration

  • Spleen anatomy

    Spleen anatomy - illustration

    The spleen is an organ that filters the blood, stores blood cells, removes old red blood cells, and produces certain white blood cells.

    Spleen anatomy

    illustration

 

Review Date: 8/18/2025

Reviewed By: LaQuita Martinez, MD, Department of Obstetrics and Gynecology, Emory Johns Creek Hospital, Alpharetta, GA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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